A Case Report on Meropenem and Valproic Acid Drug-Drug Interaction Induced Status Epilepticus

Valproic acid and meropenem is generally co-administrated in neurosurgical cases. Meropenem potentially decreases thevalproic position, which may beget perioperative turn like seizure. Such serious adverse effect through potential interactionshould be taken seriously made aware by clinicians. Among various neurological emergencies status epilepticus one ofthe most important as it progresses, therapeutic control becomes difficult. Patients receiving antiepileptics carbapenemgroup antibiotics concomitantly should closely monitored due to possible drug interaction between these agents. Theauthors report a case of 39-year-old male patient who was admitted with C4-C5 type C injury deficit dueto road traffic accident. His Glasgow Coma Scale score E4M2V1 graded ‘A’ on Asia Impairment Scale. Patient wason treatment valproic for existing schizophrenia. He empirically treated cover antibiotic forinfection phrenic nerve palsy that allowed secretions retained increase the chance infection. On third dayof admission, he developed 2 episodes breakthrough seizure less than 5 minutes. Post epileptic, Inj. Meropenemwas stopped Fosphenytoin, Midazolam Levetiracetam after whichno such seizures were observed.